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Kudzu extract

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From $25.90 / bottle(s)

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Medicinal Information

Please note that, according to our professional standards of care, we must ensure that our practitioners' only products are safe and suitable for the intended outcome. Therefore we require the submission of a Risk Assessment Form (access HERE ) prior to the supply of herbal extracts. If you are unable or unwilling to reveal personal information, please contact the pharmacy for a chat with a practitioner and an alternative solution.

Kudzu (Pueraria lobata) extract

Kudzu is an herb used in Chinese medicine to treat alcoholism, heart disease, menopausal symptoms, diabetes, fever, the common cold, and neck or eye pain. It is sometimes used in combination with other herbs. Lab studies suggest that kudzu has anti-inflammatory and neuroprotective properties. Compounds called isoflavones are thought to be responsible for its potential effects.

Studies of kudzu in humans are limited and have mostly focused on whether it can reduce alcohol intake or menopausal symptoms. However, all of these studies enrolled small numbers of patients, and systematic reviews have determined that the evidence of benefit for any condition is unclear.

Benefits:

Menopausal symptoms
Small clinical studies suggest that kudzu is a phytoestrogen that may help reduce menopausal symptoms, but a systematic review did not find benefit.
Alcohol abuse
Kudzu may reduce alcohol intake and withdrawal, but these studies enrolled only a small number of patients, and a systematic review did not find benefit.
Diabetes
Kudzu is used in traditional medicine to treat diabetes, but evidence is lacking.
Fever or common cold
Kudzu is used in traditional medicine for these purposes, but human studies are lacking.
Neck or eye pain
Kudzu is used in traditional medicine for these purposes. Although animal studies suggest kudzu may reduce inflammation and pain in combination with other herbs, human studies are lacking.

Contraidications:

Hypersensitivity to kudzu.
Hormone-sensitive cancers: Kudzu has estrogenic activity.
With tamoxifen: Isoflavones in kudzu may interfere with the effects of tamoxifen which is used for estrogen-dependent breast cancer.
With methotrexate: In animal studies, taking kudzu at the same time reduced elimination of the drug methotrexate, causing increased levels of the drug. Clinical relevance has yet to be determined.
With antidiabetic medication: Animal studies suggest a key component in kudzu may increase the activity of these medications. Clinical relevance has yet to be determined.

References:

Lukas SE, et al. An Extract of the Chinese Herbal Root Kudzu Reduces Alcohol Drinking by Heavy Drinkers in a Naturalistic Setting. Alcohol Clin Exp Res. 2005;29(5):756-62.
Chandeying V, Sangthawan M. Efficacy comparison of Pueraria mirifica (PM) against conjugated equine estrogen (CEE) with/without medroxyprogesterone acetate (MPA) in the treatment of climacteric symptoms in perimenopausal women: phase III study. J Med Assoc Thai. 2007 Sep;90(9):1720-6.
Cherdshewasart W, Sriwatcharakul S, Malaivijitnond S. Variance of estrogenic activity of the phytoestrogen-rich plant. Maturitas. 2008 Dec 20;61(4):350-7.
Penetar DM, Teter CJ, Ma Z, et al. Pharmacokinetic profile of the isoflavone puerarin after acute and repeated administration of a novel kudzu extract to human volunteers. J Altern Complement Med. 2006 Jul-Aug;12(6):543-8.
Santosh N, Mohan K, Royana S, Yamini TB. Hepatotoxicity of tubers of Indian Kudzu (Pueraria tuberosa) in rats. Food Chem Toxicol. 2010 Apr;48(4):1066-71.
Hsu FL, Liu IM, Kuo DH, et al. Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats. J Nat Prod. 2003 Jun;66(6):788-92.
Zheng J, Chen B, Jiang B, et al. The effects of puerarin on CYP2D6 and CYP1A2 activities in vivo. Arch Pharm Res. 2010 Feb;33(2):243-6.
Zhu G, Wang X, Chen Y, et al. Puerarin protects dopaminergic neurons against 6-hydroxydopamine neurotoxicity via inhibiting apoptosis and upregulating glial cell line-derived neurotrophic factor in a rat model of Parkinson’s disease. Planta Med. 2010 Nov;76(16):1820-6.
Chiang HM, Fang SH, Wen KC, et al. Life-threatening interaction between the root extract of Pueraria lobata and methotrexate in rats. Toxicol Appl Pharmacol. 2005 Dec 15;209(3):263-8.
Xing G, Dong M, Li X, et al. Neuroprotective effects of puerarin against beta-amyloid-induced neurotoxicity in PC12 cells via a PI3K-dependent signaling pathway. Brain Res Bull. 2011 May 30;85(3-4):212-8.
Penetar DM, Toto LH, Farmer SL, et al. The isoflavone puerarin reduces alcohol intake in heavy drinkers: A pilot study. Drug Alcohol Depend. 2012 Nov 1;126(1-2):251-6.
Bracken BK, Penetar DM, Maclean RR, Lukas SE. Kudzu root extract does not perturb the sleep/wake cycle of moderate drinkers. J Altern Complement Med. 2011 Oct;17(10):961-6.
Virojchaiwong P, Suvithayasiri V, Itharat A. Comparison of Pueraria mirifica 25 and 50 mg for menopausal symptoms. Arch Gynecol Obstet. 2011 Aug;284(2):411-9.
Peng J, Cui T, Huang F, et al. Puerarin Ameliorates Experimental Alcoholic Liver Injury by Inhibition of Endotoxin Gut-leakage, kupffer Cell Activation and Lipopolysaccharide Receptors Expression. J Pharmacol Exp Ther. 2013 Mar;344(3):646-54.
Lukas SE, Penetar D, Su Z, et al. A standardized kudzu extract (NPI-031) reduces alcohol consumption in nontreatment-seeking male heavy drinkers. Psychopharmacology (Berl). 2013 Mar;226(1):65-73.
Jo SJ, Shin H, Paik SH, et al. Efficacy and Safety of Pueraria lobata Extract in Gray Hair Prevention: A Randomized, Double-Blind, Placebo-Controlled Study. Ann Dermatol. 2013 May;25(2):218-22.
Penetar DM, Toto LH, Lee DY, et al. A single dose of kudzu extract reduces alcohol consumption in a binge drinking paradigm. Drug Alcohol Depend. Aug 1 2015;153:194-200.
Suwanvesh N, Manonai J, Sophonsritsuk A, et al. Comparison of Pueraria mirifica gel and conjugated equine estrogen cream effects on vaginal health in postmenopausal women. Menopause. Feb 2017;24(2):210-215.

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Kudzu extract

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