Extract of Feverfew, Tanacetum vulgare, in Ethanol and Purified Water
Feverfew (Tanacetum parthenium, Asteraceae) has been used since antiquity for a variety of medicinal purposes but prominently to alleviate fever, headache, and women’s genito-urinary ailments. Claims of efficacy for these traditional uses are almost invariably anecdotal. However, over the past 2 decades, randomized controlled trials have been conducted in the prophylaxis of migraine. While the quality of these trials vary, there is good evidence of feverfew’s potential in migraine: statistically significant reduction in frequency and severity of attacks as well as decrease of nausea and vomiting has been observed following the administration of feverfew leaf. Neither the constituent(s) of feverfew responsible for the migraine-preventing activity nor the mechanism(s) of action are yet known.
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