Methylation (MTHF)

Compounded Methylfolate, Folinic Acid & Folic Acid

Support Your Body’s Methylation Pathways with Tailored Formulations

Methylation is a vital process in your body. It helps with everything from energy production and detoxification to brain function and hormone balance. For many people, especially those with MTHFR gene variations, supporting methylation with the right form of folate is essential.

At Newton’s Compounding Pharmacy, we offer customised folate-based formulations – including Methylfolate (5-MTHF), Folinic Acid, and Folic Acid – to support optimal health when standard supplements are not effective or well tolerated.

Why Choose Compounded Folate Products?

Not all forms of folate are the same. Many people can't properly convert standard folic acid into the active form the body uses. That’s where compounded alternatives like 5-MTHF or Folinic Acid can make a difference.

Our Compounded Products May Help With:

• Fatigue or low energy

• Hormonal imbalance

• Mood issues such as anxiety or depression

• Fertility support

• MTHFR gene variations

• Support during detox or chronic illness

• Immune and nervous system support

Which Form Is Right for You?

✅ Folic Acid

• Commonly found in commercial supplements

• Requires conversion by the body

• Not effective for those with MTHFR gene variants

✅ Folinic Acid

• Easier for the body to use than folic acid

• Bypasses some metabolic steps

• Suitable for people who don’t fully convert folic acid

✅ Methylfolate (5-MTHF)

• The most active form of folate

• Ideal for people with MTHFR gene issues

• Immediately usable by the body

• Supports neurotransmitter production and detoxification

Why Compounded?

We can compound custom strengths and combinations of methylfolate, folinic acid, or folic acid into:

• Capsules

• Lozenges (troches)

• Topical creams

Our compounding allows for precision dosing, better absorption, and formulations tailored to your individual needs.

Who Might Benefit?

Compounded folate products may support people dealing with:

• MTHFR gene mutations

• Chronic fatigue

• Depression or anxiety

• Hormonal imbalances

• Fertility challenges

• High homocysteine levels

• Poor detoxification

• Pregnancy support (under medical supervision)

Important Notes:

• Always consult a doctor before beginning any new supplement.

• People with epilepsy or folate sensitivity should only use these products under supervision.

• Side effects are rare but may include nausea, flushing, or overstimulation.

Common Interactions

Certain medications can interfere with folate metabolism, including:

• Aspirin

• Cholesterol-lowering drugs

• Antacids

• Birth control pills

• Methotrexate (used in rheumatoid arthritis)

For people taking these, compounded folinic acid or methylfolate may be a better option than standard folic acid.