Globe Artichoke Extract

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From the Team at Newton's Pharmacy

Globe Artichoke Leaf (Cynara scolymus) Extract 1:1 in 30% Ethanol and Purified Water

General Information

Artichoke leaf has been used as a choleretic and diuretic in traditional European medicine since Roman times (Bianchini and Corbetta, 1977). Traditional medicinal uses of artichoke pertain to liver function. Artichoke leaf is considered choleretic (bile increasing), hepatoprotective, cholesterol-reducing, and diuretic (Kirchhoff et al., 1994). In Germany, it is used today as a choleretic (BAnz, 1998; Meyer-Buchtela, 1999) for its lipid-lowering, hepato-stimulating, and appetite-stimulating actions (Hnsel et al., 19921994; Meyer-Buchtela, 1999). In German pediatric medicine, herbs with a relatively low bitter value (8002000), such as artichoke leaf, are considered suitable for the treatment of appetite disorders (Schilcher, 1997).

Modern human studies have investigated its choleretic activity for treatment of digestive disorders (Kirchhoff et al., 1994). An article by Kraft summarized various post-marketing surveillance studies conducted on patients with dyspepsia and/or diseases of the liver or bile duct. The studies included anywhere from 417 to 557 patients and treatment duration ranged from 4 to 6 weeks. Statistically significant reduction of symptoms (e.g., abdominal pain, bloating, flatulence, and nausea) were reported for the surveillance studies referred to in this paper. Artichoke preparations were well tolerated (up to 95% of cases) with a low rate of side-effects (Kraft, 1997).

Artichoke leaf extract is derived from artichokes. This plant belongs to the daisy family and is native to areas such as southern Europe and northern Africa.

Artichokes are a delicious accompaniment to many dishes, and its leaves have been traditionally used to treat ailments like jaundice, acid reflux, and various liver disorders. There is research, however, to support the use of artichoke leaf extract to treat indigestion and high cholesterol with studies about cholesterol gaining interest.

Reference:

Rondanelli M, Giacosa A, Opizzi A, et al. Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial. Int J Food Sci Nutr. 2013;64(1):7-15. doi:10.3109/09637486.2012.700920
Standard N. Natural Standard Herb & Supplement Guide - E-Book An Evidence-Based Reference. St Louis: Elsevier Health Sciences; 2010.
Warning: Herbal extracts may interact with other therapeutic substances, or be contraindicated in certain conditions, and as a general rule are not recommended for use by children, in pregnancy and lactation, or if you are on certain prescription medications.If wondering if any of our herbal products may be of benefit to you, please complete and submit this form and get in touch by phone or email.

Disclaimer: The statements provided on this website are based on the recorded traditional use of herbs in general and should not be viewed as therapeutic claims for the herbal teas, extracts, and blends on offer. We provide this information for educational purpose to our customers and fans of herbal and natural medicine because we believe it is important to stay connected to our roots and maintain and spread the human knowledge accumulated over centuries of traditional healing. Our herbal blends are custom made in accordance with your needs and not tested for efficacy or listed on the register of therapeutic goods.

We must ensure the safe and appropriate use of our products and may ask for additional information prior to making up your product. Please rest assure that we respect your privacy and that your information will not be shared.

Information and statements regarding dietary supplements have not been evaluated by the Therapeutic Goods Administration (TGA) and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Additional product information

Medicinal Information	HERBAL MEDICINE: EXPANDED COMMISSION E MONOGRAPHS Artichoke leaf Globe artichoke is a perennial herb native to Mediterranean southern Europe and northern Africa and the Canary Islands (Leung and Foster, 1996). Its cultivation in Europe dates back to ancient Greece and Rome (Grieve, 1971). It is cultivated in North Africa as well as in other subtropical regions (Iwu, 1993). The material of commerce comes as whole or cut dried leaves obtained mainly from southern Europe and northern Africa (BHP, 1996). Artichoke leaf has been used as a choleretic and diuretic in traditional European medicine since Roman times (Bianchini and Corbetta, 1977). Traditional medicinal uses of artichoke pertain to liver function. Artichoke leaf is considered choleretic (bile increasing), hepatoprotective, cholesterol-reducing, and diuretic (Kirchhoff et al., 1994). In Germany, it is used today as a choleretic (BAnz, 1998; Meyer-Buchtela, 1999) for its lipid-lowering, hepato-stimulating, and appetite-stimulating actions (Hnsel et al., 19921994; Meyer-Buchtela, 1999). In German pediatric medicine, herbs with a relatively low bitter value (8002000), such as artichoke leaf, are considered suitable for the treatment of appetite disorders (Schilcher, 1997). Modern human studies have investigated its choleretic activity for treatment of digestive disorders (Kirchhoff et al., 1994). An article by Kraft summarized various post-marketing surveillance studies conducted on patients with dyspepsia and/or diseases of the liver or bile duct. The studies included anywhere from 417 to 557 patients and treatment duration ranged from 4 to 6 weeks. Statistically significant reduction of symptoms (e.g., abdominal pain, bloating, flatulence, and nausea) were reported for the surveillance studies referred to in this paper. Artichoke preparations were well tolerated (up to 95% of cases) with a low rate of side-effects (Kraft, 1997). In one clinical trial, 20 men with acute or chronic metabolic disorders were separated at random into two groups. The test group was given a standardized artichoke extract (Hepar SL forte, Seturner, Germany) of 320 mg in a capsule dissolved in 50 ml water, taken intraduodenally. Results were assessed by measuring intraduodenal bile secretions, which increased 127.3% after 30 minutes, 151.5% after 60 minutes, and 94.3% after 90 minutes. The relative differences for the placebo were significant. The researchers concluded that artichoke extract can be used for the treatment of digestive disorders characterized by poor assimilation of fat due to insufficient bile secretion. No adverse side effects were observed (Kirchhoff et al., 1994). Pharmacopeial grade artichoke leaf consists of the dried radical leaves of Cynara scolymus L. Botanical identification is carried out by thin-layer chromatography (TLC), macroscopic and microscopic evaluations, and organoleptic tests. The dried leaf must contain not less than 25% water-soluble extractive (BHP, 1996). Chemistry and Pharmacology Artichoke leaf contains up to 2% phenolic acids, mainly 3-caffeoylquinic acid (chlorogenic acid), plus 1,5-di -O-caffeoylquinic acid (cynarin), and caffeic acid; 04% bitter sesquiterpene lactones of which 4783% is cynaropicrin; 0.11.0% flavonoids including the glycosides luteolin-7 -b-rutinoside (scolymoside), luteolin-7 -b-D-glucoside and luteolin-4 -b-D-glucoside; phytosterols (taraxasterol); sugars; inulin; enzymes; and a volatile oil consisting mainly of the sesquiterpenes b-selinene and caryophyllene (Hnsel et al., 19921994; Leung and Foster, 1996; Meyer-Buchtela, 1999; Newall et al., 1996). The Commission E reported choleretic activity. The British Herbal Pharmacopoeia reported hepatic action (BHP, 1996). In vivo, artichoke leaf has demonstrated hepatoprotective and hepatostimulating properties (Adzet et al., 1987; Maros et al., 1966). The Merck Index reported the therapeutic category of cynarin, an active principle of artichoke, as choleretic (Budavari, 1996). The African Pharmacopoeia reported diuretic and anti-atherosclerotic actions (Iwu, 1993). Artichoke leaf has shown cholesterol-lowering and lipid-lowering activity in rats and humans (Lietti, 1977). Human studies have validated carminative, spasmolytic, antiemetic, and choleretic actions (Kraft, 1997). Uses The Commission E approved artichoke leaf for dyspeptic problems. The African Pharmacopoeia indicates its use for the treatment of liver dysfunction (Iwu, 1993). Preparations of artichoke have been used for bloating, nausea, and impairment of digestion (Bruneton, 1995). It is specifically indicated for 'dyspeptic syndrome' though its proven lipid-lowering actions suggest that it may also be useful as a prophylactic against atherosclerosis (Kraft, 1997). Contraindications Known allergies to artichokes and related species (Asteraceae or Compositae). Obstruction of bile ducts. In case of gallstones, use only after consulting a physician. Interactions with Other Drugs None known. Side Effects None known. Use During Pregnancy and Lactation No restrictions known. Dosage and Administration Unless otherwise prescribed: 6 g per day of dried cut leaves, pressed juice of fresh plant, and other equivalent galenical preparations for internal use. Leaf: 2 g, three times daily. Infusion: Artichoke leaf is not typically prepared as an infusion. Dry extract 12:1 (w/w): 0.5 g single daily dose. Fluidextract 1:1 (g/ml): 2 ml, three times daily. Tincture 1:5 (g/ml): 6 ml, three times daily. References Adzet, T. et al. 1987. Action of an artichoke extract against CC14-induced hepatotoxicity in rats. Acta Pharm Jugosl 37:183187. BAnz. See Bundesanzeiger. Bianchini, F. and F. Corbetta. 1977. Health Plants of the WorldAtlas of Medicinal Plants. New York: Newsweek Books. British Herbal Pharmacopoeia (BHP). 1996. Exeter, U.K.: British Herbal Medicine Association. Bruneton, J. 1995. Pharmacognosy, Phytochemistry, Medicinal Plants. Paris: Lavoisier Publishing. Budavari, S. (ed.). 1996 . The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals, 12 th ed. Whitehouse Station, N.J.: Merck & Co, Inc. 467-468. Bundesanzeiger (BAnz). 1998. Monographien der Kommission E (Zulassungs- und Aufbereitungskommission am BGA f r den humanmed. Bereich, phytotherapeutische Therapierichtung und Stoffgruppe). Kln: Bundesgesundheitsamt (BGA). Grieve, M. 1971. A Modern Herbal. New York: Dover Publications, Inc. 60. Hnsel, R., K. Keller, H. Rimpler, G. Schneider (eds.). 19921994. Hagers Handbuch der Pharmazeutischen Praxis, 5 th ed. Vol. 46. Berlin-Heidelberg: Springer Verlag. Iwu, M.M. 1993. Handbook of African Medicinal Plants. Boca Raton: CRC Press. 167168. Kirchhoff, R. et al. 1994. Increase in choleresis by means of artichoke extract. Phytomedicine 1:107115. Kraft, K. 1997. Artichoke leaf extractrecent findings reflecting effects on lipid metabolism, liver, and gastrointestinal tracts. Phytomedicine 4(4):369378. Leung, A.Y. and S. Foster. 1996. Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics, 2 nd ed. New York: John Wiley & Sons, Inc. 4244. Lietti, A. 1977. Choleretic and cholesterol lowering properties of two artichoke extracts. Fitoterapia (48):153-158. Maros T, G. Racz, B. Katonai, V.V. Kovacs. 1966. Wirkungen der Cynara scolymus-Extrakte auf die Regeneration der Rattenleber [Effects of Cynara scolymus extracts on the regeneration of rat liver. 1]. Arzneimforsch 16(2):127129. Meyer-Buchtela, E. 1999. Tee-RezepturenEin Handbuch f r Apotheker und rzte. Stuttgart: Deutscher Apotheker Verlag. Newall, C.A., L.A. Anderson, J.D. Phillipson. 1996. Herbal Medicines: A Guide for Health-Care Professionals. London: The Pharmaceutical Press. 3738. Schilcher, H. 1997. Phytotherapy in Paediatrics: Handbook for Physicians and Pharmacists. Stuttgart: Medpharm Scientific Publishers. 4546.

Medicinal Information

HERBAL MEDICINE: EXPANDED COMMISSION E MONOGRAPHS

Artichoke leaf

Globe artichoke is a perennial herb native to Mediterranean southern Europe and northern Africa and the Canary Islands (Leung and Foster, 1996). Its cultivation in Europe dates back to ancient Greece and Rome (Grieve, 1971). It is cultivated in North Africa as well as in other subtropical regions (Iwu, 1993). The material of commerce comes as whole or cut dried leaves obtained mainly from southern Europe and northern Africa (BHP, 1996).

In one clinical trial, 20 men with acute or chronic metabolic disorders were separated at random into two groups. The test group was given a standardized artichoke extract (Hepar SL forte, Seturner, Germany) of 320 mg in a capsule dissolved in 50 ml water, taken intraduodenally. Results were assessed by measuring intraduodenal bile secretions, which increased 127.3% after 30 minutes, 151.5% after 60 minutes, and 94.3% after 90 minutes. The relative differences for the placebo were significant. The researchers concluded that artichoke extract can be used for the treatment of digestive disorders characterized by poor assimilation of fat due to insufficient bile secretion. No adverse side effects were observed (Kirchhoff et al., 1994).

Pharmacopeial grade artichoke leaf consists of the dried radical leaves of Cynara scolymus L. Botanical identification is carried out by thin-layer chromatography (TLC), macroscopic and microscopic evaluations, and organoleptic tests. The dried leaf must contain not less than 25% water-soluble extractive (BHP, 1996).

Chemistry and Pharmacology

Artichoke leaf contains up to 2% phenolic acids, mainly 3-caffeoylquinic acid (chlorogenic acid), plus 1,5-di -O-caffeoylquinic acid (cynarin), and caffeic acid; 04% bitter sesquiterpene lactones of which 4783% is cynaropicrin; 0.11.0% flavonoids including the glycosides luteolin-7 -b-rutinoside (scolymoside), luteolin-7 -b-D-glucoside and luteolin-4 -b-D-glucoside; phytosterols (taraxasterol); sugars; inulin; enzymes; and a volatile oil consisting mainly of the sesquiterpenes b-selinene and caryophyllene (Hnsel et al., 19921994; Leung and Foster, 1996; Meyer-Buchtela, 1999; Newall et al., 1996).

The Commission E reported choleretic activity.

The British Herbal Pharmacopoeia reported hepatic action (BHP, 1996). In vivo, artichoke leaf has demonstrated hepatoprotective and hepatostimulating properties (Adzet et al., 1987; Maros et al., 1966). The Merck Index reported the therapeutic category of cynarin, an active principle of artichoke, as choleretic (Budavari, 1996). The African Pharmacopoeia reported diuretic and anti-atherosclerotic actions (Iwu, 1993). Artichoke leaf has shown cholesterol-lowering and lipid-lowering activity in rats and humans (Lietti, 1977). Human studies have validated carminative, spasmolytic, antiemetic, and choleretic actions (Kraft, 1997).

Uses

The Commission E approved artichoke leaf for dyspeptic problems.

The African Pharmacopoeia indicates its use for the treatment of liver dysfunction (Iwu, 1993). Preparations of artichoke have been used for bloating, nausea, and impairment of digestion (Bruneton, 1995). It is specifically indicated for 'dyspeptic syndrome' though its proven lipid-lowering actions suggest that it may also be useful as a prophylactic against atherosclerosis (Kraft, 1997).

Contraindications

Known allergies to artichokes and related species (Asteraceae or Compositae).

Obstruction of bile ducts.

In case of gallstones, use only after consulting a physician.

Interactions with Other Drugs

None known.

Side Effects

None known.

Use During Pregnancy and Lactation

No restrictions known.

Dosage and Administration

Unless otherwise prescribed: 6 g per day of dried cut leaves, pressed juice of fresh plant, and other equivalent galenical preparations for internal use.

Leaf: 2 g, three times daily.

Infusion: Artichoke leaf is not typically prepared as an infusion.

Dry extract 12:1 (w/w): 0.5 g single daily dose.

Fluidextract 1:1 (g/ml): 2 ml, three times daily.

Tincture 1:5 (g/ml): 6 ml, three times daily.

References

Adzet, T. et al. 1987. Action of an artichoke extract against CC14-induced hepatotoxicity in rats. Acta Pharm Jugosl 37:183187.
BAnz. See Bundesanzeiger.
Bianchini, F. and F. Corbetta. 1977. Health Plants of the WorldAtlas of Medicinal Plants. New York: Newsweek Books.
British Herbal Pharmacopoeia (BHP). 1996. Exeter, U.K.: British Herbal Medicine Association.
Bruneton, J. 1995. Pharmacognosy, Phytochemistry, Medicinal Plants. Paris: Lavoisier Publishing.
Budavari, S. (ed.). 1996 . The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals, 12 th ed. Whitehouse Station, N.J.: Merck & Co, Inc. 467-468.
Bundesanzeiger (BAnz). 1998. Monographien der Kommission E (Zulassungs- und Aufbereitungskommission am BGA f r den humanmed. Bereich, phytotherapeutische Therapierichtung und Stoffgruppe). Kln: Bundesgesundheitsamt (BGA).
Grieve, M. 1971. A Modern Herbal. New York: Dover Publications, Inc. 60.
Hnsel, R., K. Keller, H. Rimpler, G. Schneider (eds.). 19921994. Hagers Handbuch der Pharmazeutischen Praxis, 5 th ed. Vol. 46. Berlin-Heidelberg: Springer Verlag.
Iwu, M.M. 1993. Handbook of African Medicinal Plants. Boca Raton: CRC Press. 167168.
Kirchhoff, R. et al. 1994. Increase in choleresis by means of artichoke extract. Phytomedicine 1:107115.
Kraft, K. 1997. Artichoke leaf extractrecent findings reflecting effects on lipid metabolism, liver, and gastrointestinal tracts. Phytomedicine 4(4):369378.
Leung, A.Y. and S. Foster. 1996. Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics, 2 nd ed. New York: John Wiley & Sons, Inc. 4244.
Lietti, A. 1977. Choleretic and cholesterol lowering properties of two artichoke extracts. Fitoterapia (48):153-158.
Maros T, G. Racz, B. Katonai, V.V. Kovacs. 1966. Wirkungen der Cynara scolymus-Extrakte auf die Regeneration der Rattenleber [Effects of Cynara scolymus extracts on the regeneration of rat liver. 1]. Arzneimforsch 16(2):127129.
Meyer-Buchtela, E. 1999. Tee-RezepturenEin Handbuch f r Apotheker und rzte. Stuttgart: Deutscher Apotheker Verlag.
Newall, C.A., L.A. Anderson, J.D. Phillipson. 1996. Herbal Medicines: A Guide for Health-Care Professionals. London: The Pharmaceutical Press. 3738.
Schilcher, H. 1997. Phytotherapy in Paediatrics: Handbook for Physicians and Pharmacists. Stuttgart: Medpharm Scientific Publishers. 4546.

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