Nettle Seed Extract

Nettle seeds are the most nutritious part of nettle. They contain all the goodies of nettle, vitamin A and C, iron, calcium, magnesium and silicon. 

Numerous studies have reported the presence of flavonoids, saponins and anthocyanins in Urtica dioica, thus the decrease in the renal deposition of calcium and oxalate in the Urtica dioica extract-treated rats. (1-2) Saponins and flavonoids prevent calcium and oxalate deposition through disintegrating mucoproteins, which have a high affinity for calcium oxalate crystal surfaces and thus promote the growth and deposition of crystals (3). Another study revealed that the methanol extract of U. dioica efficiently dissolves calcium oxalate renal stones in male Sprague-Dawley rats. The extract showed a dose-dependent curative effect on urinary and renal parameters, including calcium oxalate renal stone formation. (4)
Urtica dioica seeds extract has a protective hepatorenal effect. The study has shown the improvement of the antioxidant system towards normality, particularly in the liver, brain, kidney and heart. (5)
The effect of stinging nettle (Urtica dioica) seed oil on experimental colitis in rats was investigated. It has shown anti-inflammatory and antioxidant actions on colonic chronic inflammation. (6)

References: 
1. Basaran AA, Akbay P, Undeger U and Basaran N: In vitro immunomodulatory and mutagenic activity of the flavonoid glycosides from Urtica dioica L. Toxicology. 164:171–172. 2001.
2. Chaurasia N and Wichtl M: Flavonol glycosides from Urtica dioica. Planta Med. 53:432–434. 1987.
3. Leal JJ and Finlayson B: Adsorption of naturally occurring polymers onto calcium oxalate crystal surfaces. Invest Urol. 14:278–283. 1977.PubMed/NCBI
4. Zhang, H., Li, N., Li, K., & Li, P. (2014). Protective effect of Urtica dioica methanol extract against experimentally induced urinary calculi in rats. Molecular Medicine Reports, 10, 3157-3162. https://doi.org/10.3892/mmr.2014.2610
5. A. Uyar, Z. Yener & A. Dogan (2016) Protective effects of Urtica dioica seed extract in aflatoxicosis: histopathological and biochemical findings, British Poultry Science, 57:2, 235-245 https://www.ncbi.nlm.nih.gov/pubmed/27389487
6. The Effect of Stinging Nettle (Urtica dioica) Seed Oil on Experimental Colitis in Rats. Zeynep Genc, Aysen Yarat, Tugba Tunali-Akbay, Goksel Sener, Sule Cetinel, Rabia Pisiriciler, Esin Caliskan-Ak, Ayhan Altıntas, and Betul Demirci, Journal of Medicinal Food 2011 https://www.ncbi.nlm.nih.gov/pubmed/2186172